The Sanctions Monitoring Board is regulated by the National Interest (Enabling Powers) Act and is comprised of eighteen officials, acting collectively and representing the following Ministries/Authorities:
- Ministry for Foreign and European Affairs and Trade (Chairman),
- Office of the Attorney General;
- Financial Intelligence Analysis Unit;
- Malta Security Services;
- Malta Police;
- Office of the Prime Minister;
- Ministry for Home Affairs;
- Ministry responsible for Defence;
- Ministry of Finance;
- Ministry responsible for the Economy;
- Trade Department;
- Customs Department;
- Central Bank of Malta;
- Malta Financial Services Authority;
- Ministry responsible for maritime affairs;
- Ministry responsible for aviation matters;
- Ministry responsible for lands;
- Ministry responsible for immigration matters.